Well-defined Polymeric Vesicles with High Stability and Modulation of Cell Uptake by a Simple Coating Protocol

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Gokcen Yasayan, Martin Redhead, Johannes P. Magnusson, Sebastian G. Spain, Stephanie Allen, Martyn C. Davies, Cameron Alexander and Francisco Fernandez-Trillo; Polym. Chem., 2012, 3, 2596-2604. [DOI] [PDF] open access logo


Amphiphilic polymers have been synthesised by controlled free radical polymerisation techniques. These polymers self-assemble into well-defined vesicles in aqueous conditions, enabling encapsulation of a model hydrophilic molecule. The polymeric vesicles show high stability against a range of aqueous conditions with marginal release of cargo, even in the presence of known cell-membrane disruptive polymers such as branched poly(ethylene imine) (b-PEI). This stability allows for inversion of the surface charge of the polymeric vesicles by a simple coating protocol leading to an enhanced uptake by mammalian cells.